Transition Basics: HRT (Hormone Replacement Therapy)

To neutralize the effects of the male hormones produced by a transsexual woman's body prior to orchidectomy (castration) and start undoing some of the masculinization that begins at puberty, hormone replacement therapy (HRT) is employed, usually via intramuscular (IM) injection, pills, transdermal patches or by some combination of two methods.

My first year back (1989) combined IM shots and oral Premarin daily. I gave myself a weekly shot of Depo-Provera except for the fourth week when my original HRT doctor gave me a shot of Delestrogen and Delalutin. From January 1990 until May '91 I took only oral hormones: Estinyl, Provera and Premarin. Liver disease forced me to discontinue HRT and have an orchidectomy (castration) so that testosterone wouldn't undo thirty months of feminization.

Hormone Replacement Therapy progression from November 1988 until May 1991

2 weeks

5 months

18 months

30 months
After my liver troubles were resolved I resumed Delestrogen in 2005, giving myself IM shots every two weeks. For a month I foolishly followed the advice of transwomen online who preach that doctors are clueless about HRT for TS women. Due to the perilously high dose they "prescribed" I nearly missed my FFS surgery when my liver enzymes shot through the roof. Here's an account of with my misadventures with peer-prescribed HRT.

Transition Basics: Electrolysis